Characterization of Cutaneous Phototoxicity Induced by Topical Alpha-Terthienyl and Ultraviolet A Radiation

    September 1986 in “ Journal of Investigative Dermatology ”
    William Rampone, Jerry L. McCullough, Gerald D. Weinstein, G.H.N. Towers, Michael W. Berns, B. Abeysekera
    TLDR Low-dose topical alpha-terthienyl may be a safer option for treating skin conditions with light therapy.
    The study investigated the phototoxic effects of alpha-terthienyl (alpha-T), a compound from marigolds, when applied topically and exposed to UVA radiation. Using guinea pig skin, researchers found that alpha-T penetrated the skin in a dose-dependent manner. When applied topically and irradiated with UVA, maximum sensitization occurred 1 hour post-application, leading to erythema, edema, crusting, erosion, and inhibited hair growth, observed 72 hours to 7 days later. Similar effects were seen with intradermal injections. The findings suggested that low-dose topical alpha-T in a nonirritating vehicle could be a safer alternative for photochemotherapy in treating psoriasis and other skin conditions.
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