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research Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata

23 citations , October 2024 in “British Journal of Dermatology”

In this study, ritlecitinib showed sustained effectiveness and a favorable safety profile in treating alopecia areata in patients aged 12 and older over 24 months, with improvements observed in hair and eyebrow regrowth and patient satisfaction.

research Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata

6 citations , March 2024 in “SKIN The Journal of Cutaneous Medicine”

In this ongoing phase 3 study, ritlecitinib demonstrated sustained efficacy up to 24 months in patients aged 12 or older with alopecia areata, showing increased response rates with or without an initial loading dose and supporting its long-term use.

research Distribution of SALT Scores with Ritlecitinib Treatment up to 24 months from the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata

November 2024 in “SKIN The Journal of Cutaneous Medicine”

This study found that daily treatment with ritlecitinib 50 mg over 24 months reduced the number of patients in the highest categories of scalp hair loss, with improvements seen in patient responses over time.

research Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Areata: 3-Year Results from the ALLEGRO Phase 2b/3 and ALLEGRO-LT Phase 3 Clinical Studies

March 2026 in “American Journal of Clinical Dermatology”

In this study, ritlecitinib 50 mg produced clinically meaningful improvements in scalp hair regrowth over three years for patients aged 12 and older with severe alopecia areata, with 65.1% showing substantial hair regrowth and 31.2% achieving complete regrowth, while also maintaining a consistent safety profile.

research 67 Patterns of clinical response in patients with alopecia areata (AA) treated with ritlecitinib in the ALLEGRO phase 2b/3 and ongoing, phase 3, ALLEGRO-LT studies

3 citations , November 2023 in “Journal of Investigative Dermatology”

Over 45% of patients with alopecia areata benefit from ritlecitinib, mostly within a year.

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community Phase 3 Study for PP405 officially posted

43 upvotes 1 week ago

PP405 is in a phase 3 trial for hair loss treatment, with the study expected to run until June 2028. Minoxidil and finasteride remain key treatments, with hopes for PP405 to offer a new mechanism of action.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 5 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

community Pyrilutamide phase 3 results and maintenance?

in Research/Science 4 upvotes 2 years ago

Pyrilutamide phase 3 results showed little to no significant hair regrowth, but may be sufficient for maintaining current hair density. The user is unsure due to lack of recent discussions on pyrilutamide.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community VDPHL01 phase-2/3 results comparison

in Research/Science 128 upvotes 5 months ago

The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.

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Learn

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learn HMI-115

Experimental antibody that blocks the prolactin receptor

learn Platelet-Rich Plasma

Concentrate of your own blood platelets, injected into the scalp

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.
Is shedding normal after a hair transplant? Shedding of transplanted hairs 1–8 weeks after surgery is expected, and regrowth usually starts at 3–5 months. Shock loss of nearby native hair can also happen, so ask your surgeon if shedding persists.

learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Providers say SMP usually needs a touch-up every 1 to 5 years. It fades but does not fully disappear, and removal needs laser treatment that may be incomplete.

learn Finasteride

Finasteride Results Timeline: How Long It Takes to Work, Shedding Phases, and Expected Outcomes Trial data and community reports both put the first visible changes on finasteride at roughly 3 to 6 months, with the clearest results between 6 and 12 months; some people report an early increase in shedding, but how often this happens has not been measured. The benefit lasts only while the drug is taken, it is prescription-only, and its labels warn of sexual side effects that have continued after stopping in some men, of depression and suicidal thoughts, and of breast and semen changes; some former users also report anxiety and cognitive complaints (see "Is finasteride safe?").

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Clinics

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Hair Systems
Mane PhaseRancho Cucamonga, CA · US

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