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GlossaryPrefrontal Cortex (PFC)

region of the brain responsible for decision-making and social behavior

The prefrontal cortex (PFC) is the front part of the brain's frontal lobes, located just behind the forehead. It is crucial for complex cognitive behaviors such as decision-making, problem-solving, and controlling social behavior. The PFC is also involved in personality expression and moderating social conduct, making it essential for planning and executing tasks.

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research Acetate Meliorates Depressive-Like Behaviour in a Rat Model of PCOS Through Suppression of HDAC2 Expression and DNA Methylation

1 citations, May 2022 in “Research Square (Research Square)”

Acetate helps reduce depression in rats with PCOS by lowering specific gene expression and DNA changes in the brain.

research Hedonic Sensitivity to Natural Rewards Is Affected by Prenatal Stress in a Sex-Dependent Manner

28 citations, May 2015 in “Addiction Biology”

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

research Dietary Glucoraphanin Prevents the Onset of Psychosis in Adult Offspring After Maternal Immune Activation

36 citations, January 2018 in “Scientific reports”

Eating glucoraphanin can help prevent psychosis in offspring whose mothers had immune system activation.

research Allopregnanolone Mediates the Exacerbation of Tourette-Like Responses by Acute Stress in Mouse Models

25 citations, June 2017 in “Scientific reports”

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations, January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

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community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 3 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.