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research Transdermal Permeation of Drugs in Various Animal Species

149 citations , September 2017 in “Pharmaceutics”

This review compares animal and human skin characteristics in in vitro permeation studies but reports no new results, highlighting variations and the need for better model correlations.

25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that mice lacking the 1αOHase enzyme, which is responsible for producing a key vitamin D metabolite, showed impaired epidermal differentiation and delayed recovery of skin barrier function after disruption.

research Permanent alopecia after cranial irradiation: Dose–response relationship

120 citations , October 2004 in “International journal of radiation oncology, biology, physics”

In this study, the researchers established a dose–response relationship between the hair follicle dose during cranial irradiation and the development of permanent alopecia, with other factors showing limited correlation.

research Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia

100 citations , August 2008 in “American Journal Of Pathology”

This study found that epidermal VEGF is crucial for maintaining skin barrier function in mice and may help explain psoriasis development following skin trauma due to its effects on angiogenesis and hyperplasia.

research Permeation of topically applied caffeine through human skin – a comparison of in vivo and in vitro data

82 citations , May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

The study reported that combining the Follicular Closing Technique with the Franz diffusion cell is a valuable method for investigating follicular caffeine penetration in vitro, though kinetics differ from in vivo results.

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Community Join

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community RU58841 Permanently Fixed Balding In Unexpected Way.

in Satire 123 upvotes 10 months ago

The user humorously describes trying various hair loss treatments, including minoxidil, finasteride, and RU58841, with a satirical twist involving psychedelic experiences and imaginary entities. They mistakenly used LSD instead of RU58841 and plan to continue experimenting with other substances.

community Are permanent hair gains even possible?

in Chat 13 upvotes 1 year ago

Hair regrowth from treatments like minoxidil, RU58841, and finasteride is not permanent; stopping these treatments typically results in hair loss resuming. Beard hair can become permanent with minoxidil use, unlike scalp hair, which requires ongoing treatment to maintain gains.

community Minoxidil permanent face changes?

4 upvotes 4 years ago

Excessive use of topical minoxidil led to unwanted facial changes and side effects. The user plans to switch to oral minoxidil with microneedling for hair regrowth.

community Does Nuking Scalp DHT Theoretically Make Minoxidil Gains Permanent?

in Minoxidil 36 upvotes 1 year ago

Minoxidil gains are not permanent without continued use, even with DHT suppression. Combining treatments like Dutasteride, Finasteride, and RU58841 may help maintain hair, but stopping Minoxidil typically results in hair loss.

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Learn

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learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.
Are NeoGraft results permanent? Transplanted hair from NeoGraft is permanent, but surrounding hair may still thin.
Is a beard transplant permanent? Beard transplants are generally considered a permanent solution for facial hair loss.
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learn Platelet-Rich Plasma

Are Platelet results permanent, or does hair loss return once treatment stops? Hair loss typically returns after stopping PRP treatment, as effects are not permanent.

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Clinics

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Experts

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Dermatologist
Maya Permata Sari
Indonesia

Maya Permata Sari