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research A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population

21 citations , March 2015 in “Neurological Sciences”

This study reports that a novel frameshift mutation in the HTRA1 gene in a CARASIL pedigree led to reduced HTRA1 protein and increased TGF-β1 expression, potentially causing severe CARASIL and peripheral small arterial disease.

research Peripheral Arterial Disease: Diagnosis and Management

101 citations , August 2008 in “Mayo Clinic Proceedings”

This article reviews current understanding and management of peripheral arterial disease and reports no new results; the authors emphasize early diagnosis and lifestyle modification for better outcomes.

research Peripheral Arterial Disease: Diagnosis and Management

27 citations , August 2008 in “Mayo Clinic proceedings”

This review discusses the diagnosis, management, and treatment options for peripheral arterial disease and does not report new clinical findings; the authors emphasize the need for early diagnosis and comprehensive management.

research Evaluation of Patient with Peripheral Arterial Disease: General Surgeons’ Perspective

January 2025

In this study, researchers emphasized the escalating burden of peripheral arterial disease in India due to increasing diabetes prevalence, compounded by a shortage and urban concentration of vascular surgeons, necessitating that general surgeons enhance their diagnostic skills.

research Androgens and Cardiovascular Disease

658 citations , June 2003 in “Endocrine reviews”

This review discusses the role of androgens in the progression of cardiovascular disease and explores novel therapeutic targets without reporting new clinical results.

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community Anyone read oral minoxidil's leaflet?

4 upvotes 1 year ago

Oral minoxidil is discussed, highlighting potential cardiovascular risks at high doses, but users note that lower doses commonly used for hair loss are generally considered safe. Monitoring by doctors is advised, and some users report taking it without issues, comparing its risks to those of common medications like ibuprofen.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community How do athletes maintain their hair transplants? Or do they not?

in Transplants 57 upvotes 1 year ago

Athletes often use finasteride to maintain hair transplants, but some avoid it due to potential hormonal effects. Notable examples include Mo Salah and Conor McGregor, while LeBron James has had multiple procedures with varying success.

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