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research Frontal Fibrosing Alopecia: A Case Report of a 66-Year-Old Caucasian Woman

July 2015 in “Journal of the Dermatology Nurses’ Association”

A 66-year-old woman experienced hair loss due to Frontal Fibrosing Alopecia, a condition with no consistently effective treatment, but it usually stabilizes over time. More research is needed for better understanding and treatment options.

research Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

175 citations , December 2014 in “PLoS Biology”

Macrophages help activate hair follicle stem cells, affecting hair growth and skin repair.

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

134 citations , July 2020 in “Experimental dermatology”

Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.

research Neuroimmunoendocrine Circuitry of the Brain-Skin Connection

293 citations , November 2005 in “Trends in Immunology”

Stress can worsen skin conditions and stop hair growth by affecting the body's stress response system.

research Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions

61 citations , September 2010 in “Journal of Dermatological Science”

Stress hormones and autoimmune reactions can cause hair loss.

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community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

in Research/Science 27 upvotes 4 years ago

N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 1 month ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community Why is my dermatologist strictly against derma stamping/derma rolling?

in Microneedling 27 upvotes 9 months ago

Dermatologists often advise against at-home microneedling due to risks of scarring, infection, and improper technique. Professional guidance is recommended for safe and effective use, with some users reporting positive results when done correctly.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 407 upvotes 10 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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