research Perforins Expression by Cutaneous Gamma Delta T Cells
This review explores the expression of Perforin by gamma delta T cells in human skin and its role in cytotoxicity but reports no new experimental results.
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5 / 176 results research Association of Perforin and Granzyme-B Levels with Hyperandrogenism in Polycystic Ovary Syndrome: A Case-Control Study
This study suggests that perforin/granzyme-B might play a role in the interaction of sex hormones in patients with polycystic ovary syndrome.
research The emergence of Alopecia Areata is not dependent on perforin-mediated cytolysis
This study found that in mice, perforin-mediated cytolysis by CD8 T cells is not necessary for the autoimmune attack on hair follicles in alopecia areata, suggesting other mechanisms are responsible for disease progression.
research CD8 T cells require IFNg to induce disease in a murine model of Alopecia Areata 2310132
This study in a murine model of alopecia areata found that IFNg is crucial while perforin is not necessary for CD8 T cell-mediated disease development.
research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders
This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.
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