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research Increased risk of severe course of pemphigus in patients with pemphigus‐associated alopecia: a prospective observational study

2 citations , September 2018 in “Clinical and Experimental Dermatology”

This study found that pemphigus-associated alopecia indicates severe and treatment-resistant pemphigus, with higher disease activity and antibody levels compared to patients without alopecia.

research A case of cicatricial alopecia associated with pemphigus: a case report

June 2023 in “Dermatology reports”

In this report, the authors describe the case of an 83-year-old woman initially diagnosed with atrophic actinic keratosis, but further examination and skin biopsies at their clinic suggested the presence of an inflammatory disease, highlighting the challenges in diagnosing pemphigus.

research No mucosal involvement in a patient with paraneoplastic pemphigus associated with thymoma and myasthenia gravis

29 citations , July 2008 in “British Journal of Dermatology”

This case report examines a patient with myasthenia gravis, invasive thymoma, and paraneoplastic pemphigus associated with alopecia areata, notably without the usual mucosal involvement.

research A Case of Pityriasis Rubra Pilaris Associated with Myasthenia Gravis

December 2011 in “Journal of the Turkish Academy of Dermatology”

This case study describes a patient with myasthenia gravis associated with pityriasis rubra pilaris, suggesting a rare coexistence of these conditions.

research Dermatologic Diseases

7 citations , December 2011 in “Elsevier eBooks”

The document concludes that early diagnosis and treatment are crucial for managing skin diseases in ferrets.

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

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community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser

2 upvotes 2 years ago

Exosomes combined with fractional picosecond laser treatment were effective in treating androgenetic alopecia and promoting repigmentation in white hair patches. The role of exosomes in hair repigmentation, particularly in conditions like poliosis, is not well-studied.

community Pelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Presented at the American Academy of Dermatology (AAD) Annual Meeting 2026

122 upvotes 6 months ago

PP405 shows promise in regenerating hair by activating dormant follicles. Other treatments like VDPHL01 and Breezula are also advancing, providing new hope for hair loss solutions.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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