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research The PDGF/PDGFR pathway as a drug target

182 citations , November 2017 in “Molecular Aspects of Medicine”

This review discusses various therapeutic strategies targeting platelet-derived growth factor signaling in diseases like cancer and atherosclerosis, and evaluates existing treatments without presenting new clinical data.

research PDGF isoforms induce and maintain anagen phase of murine hair follicles

136 citations , June 2006 in “Journal of Dermatological Science”

This study found that injecting PDGF-AA and -BB into mouse skin immediately triggered the hair growth cycle's anagen phase, suggesting potential treatment options for certain types of alopecia.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

106 citations , October 2016 in “Cell Stem Cell”

This study found that PDGFA is critical for the proliferation and maintenance of adipocyte stem cells in skin but not other white adipose tissues, highlighting unique regulatory mechanisms in different tissue depots.

Pharmacological Activity and Clinical Use of Polydeoxyribonucleotide

research Pharmacological Activity and Clinical Use of PDRN

80 citations , April 2017 in “Frontiers in Pharmacology”

This review examines experimental and clinical evidence on PDRN, a drug derived from salmon DNA that acts via the adenosine A2A receptor and shows promise for tissue repair and treatment of diabetic foot ulcers in regenerative medicine.

research Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B

72 citations , January 2012 in “Annals of Dermatology”

In this study, IGF-I was shown to enhance human hair follicle growth, maintain the anagen phase, and increase expression of certain growth factors and anti-apoptotic markers.

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community EveryChem 3HP / PP30 page data vs NMR PDFs in their website : metadata mistake or document mismatch?

in Research/Science 15 upvotes 5 months ago

There is an inconsistency between the molecular weight and formula listed on EveryChem's product page and the analytical PDFs for 3HP and PP30, suggesting a possible error in the product description. Concerns are raised about EveryChem's business practices and lack of transparency in testing and manufacturing.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

11 upvotes 2 years ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Has anyone used topical spironolactone for hair loss? Especially in the temples?

in Treatment 1 upvotes 1 year ago

The conversation discusses using topical spironolactone for temple hair loss, alongside low-dose minoxidil and possibly PDRN injections, without finasteride or dutasteride. The user is skeptical about the injections due to cost and mild hair loss severity.

community 37m 2 month progress. Looks promising?

23 upvotes 2 months ago

A 37-year-old is using 1mg oral finasteride, 5mg oral minoxidil, exosome treatments, TED, NOUVADerm, weekly microneedling, and PDO threads for hair loss. Users suggest waiting a few more months to see significant progress.

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learn Beta Polypeptide

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