3 citations
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February 2022 in “Journal of Dermatological Science”
This study identified clinical features and genetic variants associated with early onset female pattern hairloss, highlighting decreased hair shaft density and specific SNPs related to androgenic features.
January 2023 in “Advances in reproductive sciences”
This study found that women with PCOS and female androgenetic alopecia had significantly higher serum pannexin-1 channel levels compared to those without PCOS, suggesting a potential role in hairloss etiology.
April 2025 in “Indus journal of bioscience research.”
This study observed that among patients with PCOS, hirsutism was present in 75.63%, acne in 65%, and other skin conditions such as female pattern hairloss, acanthosis nigricans, and seborrhea in varying proportions, highlighting the dermatological impact of PCOS on patients' quality of life.
26 citations
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January 2013 in “BioMed Research International”
This review discusses the hormonal influences on hair cycling disorders in post-partum and postmenopausal women and notes the lack of evidence for effective targeted treatments.
A user with PCOS experienced hairloss and found success using a triple dose of O.N.E Omega by Pure Encapsulations after discovering low Omega fatty acids. Biotin provided minimal improvement, but the Omega supplement significantly restored hair.
OP shares their experience with PCOS-relatedhairloss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.
High sugar diets may worsen hairloss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hairloss.
A woman with androgenic hairloss, likely due to PCOS, is seeking topical treatments as oral medications are not an option. Suggested treatments include topical finasteride, spironolactone, and clascoterone, with spironolactone and clascoterone being safer options due to lower systemic absorption risk.
The conversation is about using minoxidil for hairlossrelated to iron deficiency. The user experienced reduced hairloss after taking iron supplements and questions the need for minoxidil, which is typically used for hairloss from DHT.
Does metformin help control DHT levels that trigger androgenic alopecia?Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.
Can a zinc deficiency directly cause hair thinning or increased shedding?Studies link low serum zinc to diffuse shedding and alopecia areata, and severe deficiency states cause hair loss that reverses when zinc is replaced. The evidence is mostly observational, the one supplementation study was small and uncontrolled, and zinc is not a treatment for pattern hair loss.
How long does it take for cyproterone to work on hairloss?There is no reliable published figure for how fast cyproterone works on hair loss: the hair cycle means nothing shows for months, the one randomised trial assessed women at twelve months, and community reports range from about six months to two years — with some people seeing no change at all.