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research Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression?

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Linalool in personal care products may contribute to hair loss by damaging hair follicle stem cells and triggering harmful immune responses.

research Melatonin Protects K15+ Human Hair Follicle Stem Cells Against Paclitaxel-Induced Damage Ex Vivo

May 2023

Melatonin may protect hair follicle stem cells from damage caused by chemotherapy.

research Melatonin Protects K15+ Human Hair Follicle Stem Cells Against Paclitaxel-Induced Damage Ex Vivo

April 2023 in “Journal of Investigative Dermatology”

Melatonin may help prevent hair loss caused by the chemotherapy drug paclitaxel.

research Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression by Inducing Epithelial Hair Follicle Stem Cell Damage and MICA Expression in the Bulge?

September 2022

Linalool in personal care products may worsen frontal fibrosing alopecia by damaging hair follicle stem cells and triggering harmful immune responses.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations, April 2018 in “Trends in Molecular Medicine”

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

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community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community “Progress” pictures. Should I just give up?

in Journals / Progress Pictures 237 upvotes 1 month ago

The user has been using Finasteride and Minoxidil for hair loss but has seen no progress. Suggestions include trying Dutasteride, increasing Minoxidil dosage, or considering a hair transplant.

community Proposed new pathogenesis model for androgenetic alopecia (AGA)

in Research/Science 8 upvotes 1 year ago

The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

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