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GlossaryParathyroid Hormone-CBD (Parathyroid Hormone-Collagen Binding Domain)

modified parathyroid hormone targets collagen in bone for treatment

Parathyroid Hormone-CBD (PTH-CBD) is a modified form of parathyroid hormone that includes a collagen binding domain. This modification allows the hormone to specifically target and bind to collagen in the bone matrix, potentially enhancing its effectiveness in treating conditions like osteoporosis by promoting bone growth and repair more efficiently.

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Comparison of Ruxolitinib and a Collagen-Targeted PTH-Based Hair Cycle Stimulant on Hair Follicle Counts and Hair Growth in the C3H/HeJ Engrafted Mouse Model of Alopecia Areata

research Comparison of Ruxolitinib and a Collagen-Targeted PTH-Based Hair Cycle Stimulant on Hair Follicle Counts and Hair Growth in the C3H/HeJ Engrafted Mouse Model of Alopecia Areata

May 2023

The PTH-CBD injection improved hair regrowth better than the daily ruxolitinib pill in mice.

Parathyroid Hormone Linked to a Collagen Binding Domain Promotes Hair Growth in a Mouse Model of Chemotherapy-Induced Alopecia in a Dose-Dependent Manner

research Parathyroid Hormone Linked to a Collagen Binding Domain Promotes Hair Growth in a Mouse Model of Chemotherapy-Induced Alopecia in a Dose-Dependent Manner

8 citations , April 2014 in “Anti-Cancer Drugs”

A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.

research A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone–Collagen Binding Domain (PTH–CBD), Results in Sustained Increases in Bone Mineral Density for Up to 12 Months in Normal Female Mice

23 citations , July 2012 in “Calcified Tissue International”

A single injection of PTH–CBD can increase bone density for up to a year.

Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

research Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

20 citations , September 2013 in “Anti-Cancer Drugs”

PTH-CBD could help prevent and treat hair loss caused by chemotherapy in mice.

A Single Subcutaneous Dose of BMD-1141 Stimulates Hair Regrowth Comparable to Daily High-Dose Ruxolitinib in a Mouse Model of Alopecia Areata

research A Single Subcutaneous Dose of BMD-1141 Stimulates Hair Regrowth Comparable to Daily High-Dose Ruxolitinib in a Mouse Model of Alopecia Areata

August 2025 in “PubMed”

BMD-1141 effectively regrows hair in alopecia areata with less frequent dosing than current treatments.

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community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community My muscles & butt are disappearing on finas, and I’m only taking it because my hair was vanishing too. Help! Details below.

in Finasteride/Dutasteride 7 upvotes 5 years ago

A 39 year old female who has been taking finasteride for 1.5 months and is experiencing side effects such as muscle and butt shrinkage, and weight loss despite still having tight clothing. The user is seeking advice from those with knowledge of bodybuilding and hormones to help figure out the issue.