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Glossaryp75 neurotrophin receptor (p75)

protein on cell surfaces regulating survival and apoptosis

The p75 neurotrophin receptor (p75NTR) is a protein found on the surface of certain cells, including neurons and hair follicle cells. It plays a crucial role in regulating cell survival, growth, and apoptosis (programmed cell death) by binding to neurotrophins, which are a family of proteins that promote the survival and function of neurons. This receptor is significant in both the development of the nervous system and in conditions like alopecia, where it can influence hair follicle health and regeneration.

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A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations, October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

P75 Neurotrophin Receptor Antagonist Retards Apoptosis-Driven Hair Follicle Involution (Catagen)

research P75 Neurotrophin Receptor Antagonist Retards Apoptosis-Driven Hair Follicle Involution (Catagen)

24 citations, January 2003 in “Journal of Investigative Dermatology”

Blocking a specific receptor slows down hair loss in mice.

New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

research New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

12 citations, April 2020 in “British Journal of Dermatology”

Caffeine may help reduce stress-induced hair loss.

Probing the Effects of Stress Mediators on the Human Hair Follicle

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations, December 2007 in “American Journal of Pathology”

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Molecular Biology of Hair Morphogenesis: Development and Cycling

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations, August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

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