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GlossaryCYP17A1 (P450c17)

enzyme crucial for steroid hormone production

CYP17A1, also known as Cytochrome P450 17A1, is an enzyme that plays a crucial role in the production of steroid hormones. It is involved in the conversion of pregnenolone and progesterone into their 17-alpha-hydroxylated products, which are precursors for androgens and estrogens. This enzyme is essential for the synthesis of hormones that regulate various bodily functions, including metabolism, immune response, and sexual development.

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research A Review of Hyperandrogenism State in Polycystic Ovarian Syndrome

November 2023 in “International journal of reproduction, contraception, obstetrics and gynecology”

Polycystic ovary syndrome causes high male hormone levels, leading to symptoms like excess hair, acne, and fertility problems.

research Detection of Urine Metabolites in Polycystic Ovary Syndrome by UPLC Triple-TOF-MS

23 citations, June 2015 in “Clinica Chimica Acta”

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

research A Prospective Study of the Prevalence of Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain

491 citations, July 2000 in “The Journal of Clinical Endocrinology and Metabolism”

Polycystic ovary syndrome is found in 6.5% of unselected Caucasian women in Spain.

research Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review

343 citations, December 2008 in “Endocrine Reviews”

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

research A Prospective Study of the Prevalence of Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain

298 citations, July 2000 in “The Journal of Clinical Endocrinology and Metabolism”

About 6.5% of young Caucasian women in Spain have polycystic ovary syndrome.

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