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research Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

1 citations, October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Vitamin B3 may help prevent hair loss and promote hair growth by protecting scalp cells from stress and reducing hair growth-blocking proteins.

research Induction of Type 17 Collagen Decreases Ultraviolet B-Induced Cellular Senescence in Human hTert/KER-CT Keratinocytes

August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.

research Molecular Regulation of Melanocyte Senescence

85 citations, July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage

30 citations, November 2013 in “PLOS ONE”

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse

March 2023

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 742 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.