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research Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

1 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Vitamin B3 may help prevent hair loss and promote hair growth by protecting scalp cells from stress and reducing hair growth-blocking proteins.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated With Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Induction of Type 17 Collagen Decreases Ultraviolet B-Induced Cellular Senescence in Human hTert/KER-CT Keratinocytes

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.

Camellia Japonica Seed Extract Promotes Hair Growth by Preventing Dermal Papilla Cell Senescence and Activating Hair Follicle Stem Cells

research Camellia Japonica Seed Extract Promotes Hair Growth by Preventing Dermal Papilla Cell Senescence and Activating Hair Follicle Stem Cells

July 2025 in “Biotechnology and Bioprocess Engineering”

Camellia japonica seed extract helps hair grow by activating hair follicles and preventing cell aging.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 738 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

in Research/Science 6 upvotes 7 months ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.