February 2023 in “IntechOpen eBooks” This article discusses the various administration methods and considerations for testosterone replacement therapy, highlighting the importance of individualized therapeutic monitoring and potential adverse effects, but reports no new clinical results.
6 citations
,
November 2010 in “International Journal of Andrology” In a clinical trial, this study found that a modified slow-release oral testosterone formulation improved pharmacokinetics, delaying serum testosterone peaks and reducing serum DHT compared to immediate-release formulations, especially when combined with finasteride.
11 citations
,
April 2020 in “Andrology” This study found that testosterone replacement therapy, especially intramuscular administration, significantly increased PSA levels compared to placebo, while a significant correlation between PSA and testosterone was observed in non-BPH patients.
122 citations
,
November 2014 in “BMC Medicine” This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.
23 citations
,
March 1994 in “Fertility and sterility” This study found that oral contraceptives effectively suppressed hyperandrogenemia in most patients with hyperandrogenic-insulin-resistant acanthosis nigricans syndrome, though GnRH-a therapy was beneficial for those not responding initially.
