research Sex Differences in Opioid-Mediated Effects: Role of Androgens
Men and women react differently to opioids, with hormones potentially influencing these differences.
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research Low-Dose Naltrexone: A Novel Adjunctive Treatment in Symptomatic Alopecias?
Low-dose naltrexone might be a cheap and effective additional treatment for hair loss with scalp discomfort due to its anti-inflammatory effects and few side effects.
research The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes Through the β-Arrestin Pathway
Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.
research Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells
Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.
research Expression of Mu-Opiate Receptor in Human Epidermis and Keratinocytes
μ-opiate receptors in skin cells may affect skin health and healing.
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5 / 25 resultscommunity Quitting kratom stopped my hairloss by 80%
Quitting kratom reduced hair loss by 80% for a 23-year-old male. Others discussed kratom's effects and potential side effects on hair health.
community Microneedling as monotherapy? Combined with castor-, peppermint- and rosemary oil + coffein. Does it work?
The conversation discusses using microneedling combined with castor, peppermint, rosemary oils, and caffeine as a treatment for mild hair loss, aiming to stop or slow down hair loss and potentially regrow hair. The effectiveness of this treatment without side effects is uncertain, and it may slow hair loss but results vary.
community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)
Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.
community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV
Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.
community So we’re just ok with taking a research chemical now?
The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.