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Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia

research Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

24 citations , March 2011 in “British Journal of Dermatology”

This study found evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia.

research 564 Vertex and Occipital Intermediate and Terminal Hair Follicles from Androgenetic Alopecia Patients are Differentially Affected by Testosterone Ex Vivo

November 2022 in “Journal of Investigative Dermatology”

This study found that testosterone impacts hair follicles from different scalp regions differently in male pattern androgenetic alopecia, challenging the belief that occipital scalp follicles are androgen-insensitive.

The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

research The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

October 2024 in “Experimental Dermatology”

This study examined hair follicles from 14 Caucasian males and found that catagen-phase follicles were more prevalent (7.5%) than previously reported, challenging the established view that telogen-phase follicles are more common.

research Hair Follicles of Anterior Parietal Region are More Vulnerable than Occipital Region in Classic Acute Telogen Effluvium

1 citations , January 2003 in “Annals of Dermatology”

This study found that hair follicles on the anterior scalp may be more vulnerable to acute telogen effluvium than those on the occipital scalp.

research Evaluation of Hair Follicle Counts of Occipital Scalp Biopsies from Male Hair Transplant Patients in Thailand

1 citations , February 2023 in “Siriraj Medical Journal/San Sirirat”

This study found that Thai males with androgenic alopecia displayed lower average hair density in the occipital scalp compared to other Asian populations, but higher than those with advanced AGA.

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community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

community Dht kills hair, but no one says why?

in Finasteride/Dutasteride 40 upvotes 1 year ago

DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Has anyone here actually tried Shiseido’s S-DSC hair regenerative treatment in Japan?

14 upvotes 4 months ago

Shiseido's S-DSC hair regenerative treatment in Japan focuses on improving existing hair by thickening miniaturized follicles, not creating new ones. There is limited patient feedback and long-term data available.

community Does DHT Cause Complete Baldness?

in Research/Science 4 upvotes 1 year ago

Hair cloning technology is advancing, with clinical trials for improved methods expected by 2028 and 2029, potentially offering a solution for hair loss if donor follicles remain. Organtech's expansion into other biotech areas may secure funding, but the effectiveness of cloning depends on the availability of androgen-resistant donor follicles.

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