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This review discusses AR-modulating agents developed between 2012 and 2018, highlighting challenges with ligand-binding domain antagonists and proposing nonconventional approaches targeting other domains as promising strategies.

This study found that newborns with neural tube defects and their mothers had significantly lower hair zinc levels compared to controls.

This study found that transgenic mice expressing a mutant E1a oncoprotein in their skin had disturbed hair follicle maturation but did not show increased tumor development or proliferation.

This study identifies GZL626, a first-in-class degrader of the androgen receptor N-terminal domain, which may overcome resistance in advanced prostate cancer by targeting both full-length and variant receptors.