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      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn RU58841

      a potent but unapproved and potentially problematic topical anti-androgen

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

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      community Topical dutasteride is superior to oral finasteride

      in Research/Science  96 upvotes 1 month ago
      Topical dutasteride is more effective than oral finasteride for male pattern hair loss, with fewer side effects. Some prefer oral treatments for convenience, while others use topical solutions like minoxidil and dutasteride, sometimes with microneedling, for better results.

      community Novel effect of sildenafil (cialis) on hair growth

      in Research/Science  17 upvotes 3 years ago
      Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

      community Oral Minoxidil - The Hyper-Responder Concept

      in Research/Science  6 upvotes 1 month ago
      Minoxidil's effectiveness varies due to genetic differences in the SULT1A1 enzyme, affecting how well it converts to its active form, minoxidil sulfate. Hyper-responders may experience rapid hair growth and increased side effects, such as pericardial effusion, even at low doses.