research Androgens and Cardiovascular Disease
This review discusses the role of androgens in the progression of cardiovascular disease and explores novel therapeutic targets without reporting new clinical results.
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5 / 357 results research Selective androgen receptor modulators: a critical appraisal
This review critically evaluates the evidence for SARMs' tissue selectivity and suggests their clinical benefits over traditional androgens are not yet well-supported by robust evidence, underscoring the need for further head-to-head trials.
research Androgen Action in the Ovary
This review discusses the physiological roles of ovarian androgens in follicle development and atresia, emphasizing their contributions to polycystic ovary syndrome and normal follicle maturation but provides no new clinical results.
research Effects of non-contingent cocaine on 3alpha-androstanediol. I. Disruption of male sexual behavior
This study found that cocaine disrupted the relationship between certain brain androgen levels and sexual behavior in male rats, with dose-dependent effects on testosterone metabolism.
research Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid
This study describes molecular mechanisms explaining how sex and stress steroids rapidly modulate dendritic spine formation in hippocampal neurons, suggesting recovery-like effects under steroid-depleted conditions compared to intact conditions.
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5 / 1000+ resultscommunity Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found
The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.
community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)
Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.
community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive
Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.
community Possible transgenerational effects of finasteride use on male offspring? (STUDY)
Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.
community Bicalutamide effect on androgens?
Bicalutamide blocks androgen receptors, preventing testosterone and DHT from binding, which can help with hair loss but may cause feminization. It is not recommended for those who do not want feminization effects.
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1 / 801 resultslearn Pyrilutamide
highly targeted anti-androgen that might have minimal systemic effects
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