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GlossaryNon-Classical Adrenal Hyperplasia

partial enzyme deficiency causing excess androgen production

Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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research Influence of Genotype and Hyperandrogenism on Sexual Function in Women With Congenital Adrenal Hyperplasia

11 citations , August 2019 in “The Journal of Sexual Medicine”

Women with nonclassic congenital adrenal hyperplasia experience more sexual dysfunction and distress.

research Clinical and Hormonal Evaluation of Androgen Excess

1 citations , November 2007 in “Humana Press eBooks”

Most cases of high male hormone levels in women are due to polycystic ovary syndrome.

research Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred Because of Clinical Hyperandrogenism

352 citations , January 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.

research Nonclassic Adrenal Hyperplasia: Clinical Features, Diagnosis, and Treatment

55 citations , August 2008 in “Reviews in endocrine and metabolic disorders”

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

research Androgen Dependence of Hirsutism, Acne, and Alopecia in Women

105 citations , January 2009 in “Medicine”

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

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