July 2025 in “Journal of Investigative Dermatology” This study found that both desmoglein-specific and non-desmoglein autoantibodies may play active roles in Pemphigus vulgaris pathogenesis, with HLA genetics influencing autoimmune specificity.
23 citations
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November 2011 in “Journal of the European Academy of Dermatology and Venereology” This study observed that in pemphigus vulgaris patients, hair loss and alopecic patches may result from anti-desmoglein autoantibody-mediated acantholysis and inflammatory changes, leading to non-scarring alopecia with potential for regrowth after treatment.
99 citations
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January 2004 in “Journal of Biological Chemistry” This study found that methylprednisolone can block IgG-induced keratinocyte detachment in an animal model of pemphigus vulgaris, potentially by increasing the synthesis and modifying adhesion molecules.
June 2023 in “Dermatology reports” In this report, the authors describe the case of an 83-year-old woman initially diagnosed with atrophic actinic keratosis, but further examination and skin biopsies at their clinic suggested the presence of an inflammatory disease, highlighting the challenges in diagnosing pemphigus.
24 citations
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March 2018 in “Experimental Dermatology” This review explores the role of regulatory T cells in autoimmune skin disorders like alopecia areata and vitiligo, emphasizing unanswered questions and reporting no new experimental results.
