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GlossaryNuclear Magnetic Resonance Spectroscopy (NMR spectroscopy)

technique that uses magnetic fields to determine molecular structures

Nuclear Magnetic Resonance Spectroscopy (NMR) is a powerful analytical technique used to determine the structure of molecules. It works by placing a sample in a strong magnetic field and then measuring the interaction of atomic nuclei with radiofrequency waves. This interaction provides detailed information about the molecular structure, dynamics, and environment, making it invaluable in fields like chemistry, biology, and medicine.

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PH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption

research PH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption

7 citations, February 1998 in “Polymer journal”

Keratin structure in hair is stable at pH 5-6 but disrupts between pH 6-7.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations, August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research Stereocontrolled Synthesis of All Eight Stereoisomers of the Putative Anti-Androgen Cyoctol

16 citations, August 2004 in “Tetrahedron”

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

research Aromatic C-Nitrosation of a Bioactive Molecule: Nitrosation of Minoxidil

8 citations, January 2011 in “Organic and Biomolecular Chemistry”

Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.

research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

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community How to increase Pyri concentration from 0.5% to 1% wihout using more volume ( 2ml x 2 per say for example )

in Chat 6 upvotes 8 months ago

OP wants to increase pyrilutamide concentration from 0.5% to 1% while already using finasteride. Users suggest waiting for a commercial 1% solution and caution against using grey market products.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.

community Interpreting pre-finisteride blood panels

in Chat 2 upvotes 2 weeks ago

The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

community Pre-Finisteride DHT & Hormone Blood Panel

in Finasteride/Dutasteride 3 upvotes 3 weeks ago

The conversation discusses the cost and insurance coverage of a comprehensive hormone and DHT blood panel for hair loss, with a focus on finasteride treatment. The user seeks a cheaper alternative to a $700 panel recommended in a video.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 3 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.