1 citations
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June 2006 in “Experimental dermatology” In this study, researchers identified similar presence of various nicotinic and muscarinic AChRs in lesional and normal epidermis, suggesting that tobacco-delivered nicotine may exacerbate acne inversa by interacting with endogenously produced acetylcholine.
4 citations
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April 2008 in “Experimental Dermatology” This review hypothesizes that nicotine plays a crucial role in the pathogenesis of hidradenitis suppurativa by promoting inflammation and microbial growth, suggesting that anticholinergic agents might be a potential treatment strategy, but reports no new clinical findings.
April 2016 in “Journal of Investigative Dermatology” This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.
24 citations
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June 2008 in “Journal of Cutaneous Pathology” This review discusses varying views on the pathogenesis of hidradenitis suppurativa and the challenges in achieving a consensus, emphasizing the need for further research rather than providing new findings.
February 2026 in “International Journal of Molecular Sciences” In this study, the researchers found that cholinergic signaling via M4 muscarinic receptors influences hair growth, with enhanced elongation observed upon activation with bethanechol, highlighting its potential role in hair biology using mouse models.