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Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations, March 2003 in “American Journal of Pathology”

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

125 citations, September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations, December 2007 in “American Journal of Pathology”

Stress-related substance P may lead to hair loss and negatively affect hair growth.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations, August 2004 in “Journal of Investigative Dermatology”

Hair loss causes stress and affects mental health; treatment and support needed.

research The Role of Sleep in Telogen Effluvium and Trichodynia: A Commentary in the Context of the Current Pandemic

6 citations, January 2021 in “Journal of Cosmetic Dermatology”

Poor sleep during the pandemic may increase stress and worsen hair loss conditions.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 127 upvotes 4 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community He used Dutasteride for 20 years. Interview

in Treatment 105 upvotes 3 days ago

community C’est terrible - at my wits end

in Female 443 upvotes 1 year ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.