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GlossaryNeurosteroids (neuroactive steroids)

steroids produced in the brain that affect neuron function

Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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Antidepressant-Like Effect of Fluoxetine May Depend on Translocator Protein Activity and Pretest Session Duration in Forced Swimming Test in Mice

research Antidepressant-Like Effect of Fluoxetine May Depend on Translocator Protein Activity and Pretest Session Duration in Forced Swimming Test in Mice

7 citations , October 2017 in “Behavioural Pharmacology”

Fluoxetine's effectiveness as an antidepressant in mice depends on a specific protein activity and a 5-minute pretest.

research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD

59 citations , November 2018 in “Psychoneuroendocrinology”

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

research Roles of Steroid Sulfatase in Brain and Other Tissues

22 citations , January 2008 in “Physiological Research”

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

research 5α-Reductases in Human Physiology: An Unfolding Story

44 citations , July 2012 in “Endocrine Practice”

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

research 5α-Reductases in Human Physiology: An Unfolding Story

November 2012 in “Endocrine Practice”

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

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community risks with finasteride and dutasteride

in Research/Science 137 upvotes 2 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 2 years ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community The safest way to use finasteride - my research

in Finasteride 23 upvotes 8 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 1 year ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

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