research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
Martin-Perez et al. show that rapamycin's beneficial effects in a mouse model of Leigh syndrome are linked to the downregulation of protein kinase C.
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research Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin
This study found that in a mouse model of Leigh syndrome, rapamycin alters brain proteome and may extend survival by targeting protein kinase C.
research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN
This study found that FLCN deficiency in mice muscles led to increased mitochondrial biogenesis and a metabolic shift towards oxidative phosphorylation, with a similar advantage observed in FLCN-null kidney cancer cells.
research Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements
This study found that pelage abnormalities in Harlequin mutant mice are linked to severe AIF deficiency and associated with altered expression of genes related to hair structure.
research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver
This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.
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