research Targeting Cardiac Hypertrophy Through a Nuclear Co-Repressor
Targeting NCoR1 can help treat heart enlargement and dysfunction.
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5 / 85 resultsresearch A Comprehensive Investigation Into the Molecular Mechanism Responsible for Selective Androgen Receptor Modulator Tissue-Selectivity
The study investigated the molecular mechanism behind the tissue-selectivity of selective androgen receptor modulators (SARMs) by analyzing the conformation of the androgen receptor (AR) using various techniques. Despite initial challenges with biotinylation, further analysis revealed ligand-specific cofactors, notably identifying nuclear receptor corepressor (NCoR) exclusively in SARM-treated samples. This was confirmed by observing a higher degree of AR-SARM/NCoR association compared to AR-DHT/NCoR. Additionally, differences in cytoplasmic-nuclear transport and nuclear foci formation between AR-SARM and AR-DHT were noted. The findings suggested that AR-SARM complexes have distinct structural and functional properties, providing insights into the SARM tissue-selective mechanism and potential research directions.
research Surgical Therapies for Stable Vitiligo: Non-Cultured Epidermal Cell Suspension Transplantation
Transplanting skin cells is a safe, effective, and affordable treatment for vitiligo.
research Dysfunction of Hair Follicle Mesenchymal Progenitors Is Associated with Age-Related Hair Loss
Age-related hair loss is linked to the decline and dysfunction of hair follicle stem cells.
research Classification of Surgical Therapies in Vitiligo
Surgical therapies for vitiligo vary in effectiveness, with combination therapy and medical tattooing recommended for better results.
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