25 citations
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January 2021 in “Journal of drugs in dermatology” Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.
1 citations
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September 2011 in “Journal of Dermatology” A woman with a new PTCH gene mutation has both Gorlin syndrome and severe hair loss.
8 citations
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May 2019 in “Journal of dermatological treatment” Vismodegib is effective for basal cell carcinoma but has severe side effects.
November 1997 in “Open Archive (Karolinska Institutet)” This study focused on basal cell carcinoma (BCC) and the role of the human homologue of the Drosophila patched gene (PTCH) in its development. It was found that stromelysin 3 (ST3) expression in the mesenchyme surrounding BCC tumor cells correlated with tumor invasiveness and fibrosis. Research on Swedish families with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) localized the NBCCS gene to chromosome 9q22.3, identifying PTCH as the gene involved. PTCH mutations, often resulting in truncated proteins, were found in both hereditary and sporadic BCCs, with consistent overexpression of PTCH mRNA in tumor cells. This overexpression was also observed in trichoepithelioma (TE), suggesting a shared pathogenic pathway for similar skin tumors. The findings indicated a gatekeeper mechanism in skin tumorigenesis involving alterations in the PTCH signaling pathway.
13 citations
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October 2011 in “Clinical and Experimental Dermatology” Laser hair-comb therapy doesn't improve male-pattern hair loss.