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research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations , December 2018 in “Assay and Drug Development Technologies”

This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.

research A new label-free screen for steroid 5α-reductase inhibitors using LC-MS

15 citations , October 2016 in “Steroids”

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

research Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors

12 citations , March 2017 in “Medicinal Chemistry Research”

This study found that certain curcumin analogs derived from natural plant sources exhibit anti-androgen activity by inhibiting steroid 5-alpha reductase, identifying key structural features for their potency and safety in treating androgen-related conditions.

research Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves

July 2025 in “Molecules”

This study found that teak leaf extract can be effective in promoting hair growth in males with androgenic alopecia; however, significant variability in steroid 5-alpha reductase inhibitory activity among samples from different geographic origins means quality control is important for consistent therapeutic potential.

Sesquiterpene-Enriched Extract of Curcuma Aeruginosa Roxb. Retards Axillary Hair Growth: A Randomized, Placebo-Controlled, Double-Blind Study

research Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

5 citations , January 2018 in “Skin Pharmacology and Physiology”

This study found that a high sesquiterpene C. aeruginosa extract significantly reduced axillary hair growth in women compared to placebo with no apparent adverse effects.

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community Effectiveness and Safety of Hair Growth Formulation Containing Tectona grandis L.f (Teak) Leaf Extract

in Chat 33 upvotes 1 year ago

Teak leaf extract shows potential as a mild hair growth promoter for androgenic alopecia, with similar positive trends to minoxidil but without significant side effects. It can be made at home using dried teak leaves and ethanol, though its effectiveness compared to other treatments like finasteride is debated.

community 38M, Topical Min 5% + Infrared Therapy (4 Months In)

in Progress Pictures 485 upvotes 1 year ago

A 38-year-old man reports positive results using topical Minoxidil 5% and infrared therapy for hair regrowth over four months, along with Saw Palmetto and Pumpkin Seed Oil supplements. Others suggest adding Finasteride for better maintenance and discuss the role of DHT blockers.

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