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research Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens

14 citations , November 2014 in “European journal of medicinal chemistry”

This study identified 30 new compounds with significant androgen receptor binding affinity through a combination of virtual screening and in vitro testing.

Female Antiandrogens: Significance, Treatment, and Environmental Concerns

research Female Antiandrogens

1 citations , October 2017 in “Elsevier eBooks”

This review examines the effects of antiandrogens on female reproductive systems, particularly regarding environmental endocrine disruptors, and presents no new research findings.

research Herbs as Antiandrogenic Agents

June 2026

This literature review suggests that herbal extracts show promise as antiandrogenic agents for androgen-related conditions, potentially offering a natural alternative with fewer side effects than synthetic medications.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

research Recent discoveries and developments of androgen receptor based therapy for prostate cancer

17 citations , January 2015 in “MedChemComm”

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

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Community Join

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community What's the best/"safest" topical anti androgen on the market currently?

1 upvotes 11 months ago

The user experienced decreased libido with saw palmetto and is now considering topical anti-androgens like RU58841, pyrilutamide, and topical dutasteride for hair loss. Minoxidil is also mentioned as a potential addition, but the user is cautious about side effects and availability of treatments.

community 2 MONTHS ALL NATURAL HAIR REGROWTH REGIMEN & RESULTS

6 months ago

The conversation discusses using natural products like rosemary, tea tree, and aloe, along with a DIY coffee rinse to block DHT for hair regrowth, avoiding minoxidil and finasteride. Some users express skepticism about the effectiveness of natural remedies compared to conventional treatments.

community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community KX-826 and RU58841: do topical anti-androgens work?

10 upvotes 2 weeks ago

KX-826 and RU58841 are topical anti-androgens discussed for hair loss prevention, with KX-826 showing promise in trials and RU58841 having mixed anecdotal results. Users report combining these with treatments like minoxidil, finasteride, and dutasteride, with varying success and concerns about side effects.

community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 245 upvotes 1 year ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

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Learn

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learn Overview

learn Rosemary

Is it better to use rosemary in shampoo or as a natural oil? Using rosemary as a natural oil is generally more effective than in shampoo.

learn Adenosine

Adenosine: How natural is this ingredient and how does it act on the scalp? Adenosine is a naturally occurring compound that promotes hair growth by extending the anagen phase.

learn Scalp Micropigmentation

Does scalp micropigmentation look natural? Scalp micropigmentation can look natural if performed by a skilled practitioner.

learn Hair Transplant

Do hair transplants look natural? When done correctly, hair transplants can look completely natural and undetectable.
Will eyebrow transplants look natural? Eyebrow transplants can look natural if performed by an experienced specialist.

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