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research Prostaglandin D2 Enhances Testosterone Metabolism by ROS-Mediated Altered Redox Potential in Keratinocytes

September 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.

research Metabolic and Transcriptomic Reprogramming During Contact Inhibition-Induced Quiescence Is Mediated by YAP-Dependent and YAP-Independent Mechanisms

11 citations , August 2024 in “Nature Communications”

Quiescent cells have increased mitochondrial activity and ECM gene expression, but reduced glycolysis.

research Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Synthesis and Activity of 8-Substituted Benzo[c]quinolizin-3-ones as Dual Inhibitors of Human 5α-Reductases 1 and 2

9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 124 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 486 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community How much dht does Nizoral shampoo block?

in Ketoconazole 101 upvotes 4 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, and Nizoral shampoo. Nizoral's effectiveness is debated, with some suggesting it works as a weak antagonist for androgen receptors, while others attribute its benefits to anti-fungal and anti-inflammatory properties.

community What about cofactor NADPH ? Why don't we ever talk about it ?

in Research/Science 11 upvotes 1 year ago

The conversation discusses the role of NADPH in hair loss and the potential impact of creatine and B complex vitamins on hair shedding. The user theorizes that increasing NAD levels with B complex vitamins may reduce hair shedding, despite using finasteride and minoxidil for 9 months.

community A science based addition to your hair loss routine

in Research/Science 23 upvotes 1 year ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

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