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research Sirtuins pathways and redox homeostasis: a pilot study on young and old monozygotic twins

August 2015 in “Free Radical Biology and Medicine”

This study explores the correlation between sirtuins' expression, histone deacetylation, and redox status in young and old monozygotic twins to understand their role in age-related mechanisms.

research Epigenetic control of adult stem cell function

179 citations , July 2016 in “Nature Reviews Molecular Cell Biology”

This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.

research PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis

12 citations , August 2022 in “Stem cell reviews and reports”

This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by interacting with SIRT1 and PARP1, highlighting a potential mechanism for addressing aging-related diseases.

research PBX1-SIRT1 positive feedback loop attenuates ROS-mediated HF- MSC senescence and apoptosis

3 citations , April 2022 in “Research Square (Research Square)”

In this study, the researchers identified a PBX1-SIRT1-PARP1 axis that plays a crucial role in reducing senescence and apoptosis in hair follicle-derived mesenchymal stem cells.

research Niche-dependent immunometabolic regulation of tissue repair and regeneration

August 2026 in “Immunity & Inflammation”

In this review, the authors discuss how niche-specific immunometabolic regulation influences tissue repair across various organs by highlighting the complex, context-dependent interaction between immune metabolism and tissue-specific regenerative outcomes.

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community Im on 2.5 mg dutasteride, RU, 15 mg Oral Minoxidil, 300 mg Isoflavones, 1800mg NAC, 1000mg Pumpkin Seed Oil, NAD+ and Vipelin

21 upvotes 3 years ago

The user improved their hair loss from a Norwood scale 2.5/3 to 1.5/2 using treatments including 2.5 mg dutasteride, RU58841, 15 mg oral minoxidil, isoflavones, NAC, pumpkin seed oil, NAD+, and Vipelin, but still experiences temple recession. Other users expressed concern over the high dosages of oral minoxidil and dutasteride.

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