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Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update

52 citations , October 2012 in “Journal of Dermatological Science”

This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.

research Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene

January 2017 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

This study found that in transgenic mice overexpressing a mutant hairless gene, changes in its expression affected hair loss and regrowth, implicating the gene's role in hair follicle biology.

Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables

86 citations , December 2001 in “Experimental dermatology”

This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.

research Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements

4 citations , December 2020 in “Mammalian genome”

This study found that pelage abnormalities in Harlequin mutant mice are linked to severe AIF deficiency and associated with altered expression of genes related to hair structure.

research Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity

December 2022 in “Biochemical and Biophysical Research Communications”

This study found that HtrA2 inactivation in mnd2 mice is associated with delayed hair cycle phases and growth retardation of adipocytes, suggesting HtrA2's role in regulating adipogenesis-related hair growth.

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community King thutmose IV kept his hair for 7000 years, was he on finasteride?

in Satire 867 upvotes 9 months ago

King Thutmose IV's hair retention is humorously speculated to be due to treatments like finasteride, minoxidil, or other unconventional methods. The discussion includes jokes about genetics, ancient practices, and modern hair loss solutions.

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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