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research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

140 citations , February 2014 in “Neuron”

This study found that the opioid system, particularly via the delta opioid receptor, broadly regulates cutaneous mechanosensation, including touch, and suggests targeting this receptor could alleviate injury-induced mechanical hypersensitivity.

research Expression of μ-Opiate Receptor in Human Epidermis and Keratinocytes

111 citations , August 1998 in “Journal of Investigative Dermatology”

This study found that human epidermal keratinocytes express a functional μ-opiate receptor at both the mRNA and protein levels, potentially playing a role in skin physiology and pathology.

Hair Growth Promotion by Delta-Opioid Receptor Activation

research Hair Growth Promotion by δ-Opioid Receptor Activation

1 citations , June 2021 in “Biomolecules & Therapeutics”

In this study, researchers found that activating the delta opioid receptor with a specific agonist significantly promoted hair growth in mice, suggesting potential for developing new hair-loss treatments.

research The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

January 2024 in “Cells”

This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.

research Sex Differences in Opioid-Mediated Effects: Role of Androgens

October 2020 in “Authorea (Authorea)”

This review discusses the influence of androgens on opioid-mediated effects and calls for further research into their role in sex differences and potential therapeutic options for chronic pain and substance use disorders.

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community Quitting kratom stopped my hairloss by 80%

in Research/Science 67 upvotes 2 years ago

Quitting kratom reduced hair loss by 80% for a 23-year-old male. Others discussed kratom's effects and potential side effects on hair health.

community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)

in Research/Science 17 upvotes 1 year ago

Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.

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