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research Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice

14 citations , July 2007 in “Lupus”

In this study, repeated pregnancies in a murine model of systemic lupus erythematosus altered skin inflammation and cytokine expression but worsened kidney function and survival compared to controls.

research Immunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus

12 citations , June 2020 in “Lupus”

This study found that treating a murine model of systemic lupus erythematosus with early and optimally dosed mesenchymal stem cells effectively suppressed disease severity.

research IL-3 contributes to development of lupus nephritis in MRL/Ipr mice

40 citations , July 2015 in “Kidney International”

This study found that blocking interleukin-3 improved lupus nephritis symptoms in MRL/Ipr mice, suggesting IL-3 may play a role in the disease's progression.

research A(1-7) reduces pathologies associated with SLE in MRL-lpr mice

May 2018 in “The Journal of Immunology”

In this study, daily treatment with angiotensin (1-7) significantly reduced disease severity in a mouse model of Systemic Lupus Erythematosus, suggesting potential for Mas agonists in future therapies.