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Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Characterizing The Expression Of Metabolic Markers In Alopecia Areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The research identified unique metabolic activities in immune cells associated with hair loss in Alopecia Areata.

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

202 citations , August 2017 in “Nature cell biology”

Lactate production is important for activating hair growth stem cells.

research The Force Is Strong with This One: Metabolism Overpowers Stem Cell Fate

33 citations , March 2018 in “Trends in cell biology”

Metabolism plays a key role in determining stem cell fate.

research Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle

11 citations , October 2017 in “Journal of Investigative Dermatology”

Applying certain inhibitors to the skin can promote hair growth without harming cells.

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community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community How Veradermics secured a total of $220 million in series B and C financing for oral minoxidil, I will never understand.....

in Chat 38 upvotes 4 months ago

Veradermics' oral minoxidil shows promise for hair regrowth, with some users reporting significant improvements, while Pelage's PP405 results are less convincing and lack transparency. There is skepticism about both treatments' long-term effectiveness and potential side effects.