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GlossaryGenetic Mosaicism (Mosaicism)

presence of different genetic cell lines within one individual

Genetic Mosaicism, also known simply as Mosaicism, refers to the presence of two or more genetically distinct cell lines within the same individual, originating from a single fertilized egg. This can result from mutations during cell division in early development, leading to some cells having different genetic makeup than others. This phenomenon can affect various tissues and organs, potentially leading to conditions like segmental vitiligo or certain forms of alopecia.

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research Acne Syndromes and Mosaicism

1 citations , November 2021 in “Biomedicines”

Understanding how acne develops in different diseases could lead to new treatments.

research Mutation of the Doublecortin Gene in Male Patients with Double Cortex Syndrome: Somatic Mosaicism Detected by Hair Root Analysis

43 citations , September 2001 in “Annals of Neurology”

Hair root analysis can effectively detect somatic mosaicism in double cortex syndrome.

research Becker's Nevus Associated with Chromosomal Mosaicism and Congenital Adrenal Hyperplasia

32 citations , April 1994 in “Journal of the American Academy of Dermatology”

High androgen levels and genetic factors likely cause Becker's nevus and related symptoms.

research Pigmentary Mosaicism: An Update

7 citations , January 2008 in “Indian Journal of Dermatology”

Pigmentary mosaicism causes skin color changes and can affect multiple body systems, but has no cure.

research CPC14 Blaschko-Linear Trichoepitheliomas: Unveiling Type 1 Segmental Mosaicism

June 2025 in “British Journal of Dermatology”

A rare skin condition in a boy is likely due to a specific genetic mutation pattern.

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