August 2023 in “Journal of Cosmetic Dermatology” This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.
January 2026 in “Burns & Trauma” This review synthesizes evidence on how RNA modifications affect wound healing, particularly in skin, bone, and corneal injuries, emphasizing potential therapeutic strategies for burns and trauma in relation to these cellular processes.
2 citations
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January 2022 in “Oxidative Medicine and Cellular Longevity” This study suggests that exosomes from dermal papilla cells can regulate hair follicle stem cell proliferation via the Wnt3a/β-catenin signaling pathway, potentially informing treatment for human hair problems.
February 2023 in “International Journal of Molecular Sciences” This study found that exosomes derived from dermal papilla cells can enhance the proliferation of hair follicle stem cells by stimulating the LEF1 pathway, offering insights into hair follicle growth regulation.
13 citations
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May 2024 in “Frontiers in Aging” This editorial highlights recent advancements in understanding stem cell exhaustion in aging, focusing on the regulation of stem cell quiescence. Key studies reveal the importance of chromatin dynamics, exosome function, and cell cycle inhibitors like p16INK4a and p21 in maintaining stem cell homeostasis. Quiescent hair follicle stem cells (HF-SCs) have unique chromatin landscapes, and exosomes are crucial for maintaining quiescence by modulating protein synthesis. Exercise-induced stem cell activation is affected by genetic factors, such as p16INK4a deficiency. The editorial also examines the effects of mitochondrial metabolism and caloric restriction on aging oocytes and hematopoietic stem cells. Despite progress, more research is needed to fully understand the molecular mechanisms of stem cell quiescence and develop therapies for age-related diseases.