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research N6-methyladenosine (m6A)-circHECA facilitates the differentiation of SHF stem cells into hair follicle lineage through miR-449a-5p/LEF1 mediated Wnt/β-catenin pathway in cashmere goats

May 2026 in “Animal Bioscience”

This study found that m6A-circHECA enhances the differentiation of stem cells into hair follicle lineages in cashmere goats by sequestering miR-449a-5p, boosting LEF1 gene expression, and activating the Wnt/β-catenin pathway.

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

10 citations , January 2010 in “Veterinary pathology”

This study found that a newly identified mutation in the hairless gene in mice led to decreased Hr mRNA levels and changes in gene expression related to hair follicle development.

research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

81 citations , April 2009 in “Journal of Investigative Dermatology”

This review discusses the shedding phase of the hair cycle, known as exogen, and reports no new findings while analyzing related processes like club fiber formation and release.

research Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep

1 citations , January 2024 in “International journal of molecular sciences”

This study investigated the molecular mechanisms of hair follicle morphogenesis in Ordos fine-wool sheep, identifying differential genes related to primary and secondary hair follicles, and providing important insights for improving wool quality and breeding strategies.

research Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies

September 2025 in “Frontiers in Cell and Developmental Biology”

In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.

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Community Join

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Re:you (NOVOGRO) New Hair Loss Treatment Coming in August

45 upvotes 3 months ago

NOVOGRO's new hair loss treatment is questioned for its effectiveness compared to minoxidil, with skepticism about its claims and trial results. The product targets women and lacks the 5α-reductase inhibitor NV-1065, which is still in development.

community Should I take creatine if Im on fin?

9 upvotes 1 year ago

Creatine is unlikely to worsen hair loss for those on finasteride, with no strong scientific evidence linking it to increased hair loss. Many users report no negative effects on hair while using creatine.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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Learn

8 / 15 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Thymosin Beta 4

learn Epidermal Growth Factor

learn Stem Cell Factor

How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Valproic acid

What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.

learn KY19382

How does KY19382 actually stimulate dormant hair follicles to grow again? KY19382 stimulates dormant hair follicles by reactivating the Wnt/β-catenin signaling pathway.

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Clinics

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Trichology
Molecular TrichologyPowodów Drugi · PL

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas