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research Molecular Genetics of Alopecias

9 citations , January 2015 in “Current problems in dermatology”

This review highlights recent genetic research advancements in understanding hereditary hair diseases but reports no new study results, emphasizing the identification of genes related to both monogenic and polygenic hair disorders.

Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

research Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

11 citations , November 2012 in “Seminars in Cutaneous Medicine and Surgery”

This review summarizes current understanding and genetic insights into androgenetic alopecia, female pattern hair loss, and alopecia areata, noting the potential future role of molecular diagnostics, but it reports no new clinical results.

research Genetic and molecular aspects of androgenetic alopecia

24 citations , January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses advances in molecular biology and genetics related to androgenetic alopecia and reports no new clinical results.

research Genetic variants in androgenetic alopecia: insights from scalp RNA sequencing data

August 2024 in “Archives of Dermatological Research”

Certain genetic variants and pathways are linked to hair loss.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

This review discusses hormonal influences on hair growth and suggests that understanding hormone-gene interactions may improve treatment of hirsutism and alopecia, but reports no new clinical findings.

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Community Join

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community Bruteforcing alopecia or the new advent of science progress

22 upvotes 1 year ago

Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

26 upvotes 4 years ago

N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

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Learn

9 / 15 results

learn SCUBE3

a signaling molecule from dermal papilla cells being actively researched

learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Thymosin Beta 4

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.
What is TDM-105795, and why is it being studied as a potential product for hair loss and hair growth support? TDM-105795 is an experimental drug aimed at treating androgenetic alopecia to promote hair growth.

learn Azelaic Acid

azelaic acid: Does it work for all types of hair loss or just DHT? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil for female pattern hair loss, and the anti-DHT rationale rests on laboratory work; for alopecia areata, telogen effluvium and seborrhoeic dermatitis there is no trial evidence for azelaic acid at all.

learn Alfatradiol

Alfatradiol: Can it help if my hair loss is linked to DHT? The one randomised trial of topical alfatradiol — in 103 women — found hair thickness and density essentially unchanged after six months, while minoxidil improved both; its authors credited alfatradiol with slowing hair loss rather than regrowing hair. Laboratory work supports a local effect on follicular DHT, but no controlled trial in men appears to have been published.

learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

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