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research Susan Lee Lindquist (1949–2016)—pioneer in the study of cellular protein folding and disease

2 citations , December 2016 in “EMBO journal”

This obituary honors Susan Lee Lindquist for her pioneering work in cellular protein folding and genetics, highlighting her significant contributions to science and mentorship in her nearly 40-year career.

research Mechanisms of autophagy and their implications in dermatological disorders

6 citations , November 2024 in “Frontiers in Immunology”

This review examines the role of autophagy, specifically macrophage, chaperone-mediated, and microphagy, in the progression of six skin diseases, including psoriasis and systemic lupus erythematosus, illustrating its significance in cellular homeostasis.

research An investigation of the association between structural proteins and lipids with scalp hair curvature

January 2025 in “Open University of Cape Town (University of Cape Town)”

This study found that lipids are highly correlated with hair curvature while proteins are not, reporting the largest number of hair lipids and identifying novel proteins and chaperones relating to different hair types for the first time.

research A computer‐aided drug repurposing: the antibacterial agents targeting GroEL

2 citations , November 2025 in “British Journal of Pharmacology”

In this study, researchers validated a computational workflow for repurposing non-antibacterial drugs as antibacterial agents and highlighted daprodustat, combined with an efflux pump inhibitor, as a promising strategy against bacterial pathogens.

research Protein degradation: expanding the toolbox to restrain cancer drug resistance

7 citations , January 2023 in “Journal of Hematology & Oncology”

This review discusses how targeting protein degradation processes may help overcome cancer drug resistance, but reports no new clinical results and suggests further research for precise therapeutic strategies.

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Molecule PP405: A Research Team Backed By Google Ventures Has Discovered One Of The Most Promising Solutions For Hair Loss To Date

in Research/Science 479 upvotes 1 year ago

PP405 is a promising new treatment for hair loss that activates dormant stem cells in hair follicles, potentially bypassing the effects of DHT. It is currently in phase 2 trials and could be available between 2027 and 2030, but it is not considered a definitive cure.

community Another molecular pathway to promote scarless healing and regenerate hair follicles

14 upvotes 8 months ago

Carnosic acid in rosemary extract may enhance skin repair and promote hair follicle regeneration. It could be used alone or with verteporfin for scarless healing after dermal wounding.

community Intriguing Molecular Structures and Questions (DHT, Progesterone, Fin, etc)

7 upvotes 2 years ago

The conversation discusses the molecular structures of compounds that reduce DHT levels, including finasteride and Ashwagandha. It explores the potential of using Ashwagandha topically as a 5a reductase inhibitor.

community New molecule PP405 vs exercise

36 upvotes 1 year ago

PP405 targets hair follicle stem cells differently than exercise-induced lactate, suggesting exercise alone may not replicate its benefits. Minoxidil and finasteride are recommended alongside exercise for hair regrowth, with additional suggestions like spicy food and infrared exposure.

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