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research The Evolution of the Promise of Hair Cloning: How Hair Cell Cloning Will Fit Into Your Practice

1 citations , March 2022 in “Hair transplant forum international”

This review discusses potential strategies for rejuvenating miniaturizing hair follicles in androgenic alopecia but reports no new clinical results; it explores the idea of using DHT-resistant follicle preservation for long-term hair maintenance.

research Androgenetic alopecia: Update on etiology

1 citations , March 2021 in “Dermatological reviews”

This review discusses recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia in males, females, and children, but reports no new clinical results.

research Hormonal Effects on Hair Follicles

102 citations , July 2020 in “International journal of molecular sciences”

This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.

research Hair Regeneration and Rejuvenation: Pipeline of Medical and Technical Strategies

1 citations , January 2022 in “Stem cell biology and regenerative medicine”

This review discusses the potential of cell therapies using dermal papilla and dermal sheath cells for androgenetic alopecia, highlighting their ability to reverse hair follicle miniaturization but not yet achieving significant cosmetic efficacy in trials.

Ketoconazole as an Adjunct to Finasteride in the Treatment of Androgenetic Alopecia in Men

research Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men

28 citations , December 2003 in “Medical Hypotheses”

This paper suggests that ketoconazole 2% shampoo may enhance finasteride's effectiveness in treating androgenetic alopecia by more completely inhibiting the dihydrotestosterone pathway.

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Community Join

5 / 194 results

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 1 year ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

community Wouldn’t it be funny if there already was a drug that existed which reactivated sleeping follicles? It would be our own version of Ozempic

202 upvotes 1 year ago

PP405 shows promise for reactivating hair follicles, with potential maintenance using 5AR inhibitors. Current treatments like Minoxidil and finasteride are effective but have limitations, and there is hope for more effective solutions in the future.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

community Can one of you smarty pants explain the PP405 results? Why did they choose to highlight that 31% had 20% increase in density? What about the other 69%? What about other ±% in density? Why is this considered a great result? Thanks.

13 upvotes 10 months ago

PP405 shows promise in reactivating dormant hair follicles, with 31% of users experiencing a 20% increase in hair density in a short period. It may work faster than minoxidil and without side effects, but its long-term effectiveness is still uncertain.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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Learn

5 / 801 results

learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Fluridil

Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men, 9 months, double-blind and placebo-controlled) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

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Clinics

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