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GlossaryMetribolone (Methyltrienolone)

synthetic anabolic-androgenic steroid used in research, not clinically

Metribolone, also known as R1881 or Methyltrienolone, is a synthetic anabolic-androgenic steroid (AAS) that is highly potent. It binds strongly to androgen receptors, making it useful in scientific research to study androgen receptor activity. However, due to its high toxicity, it is not used clinically in humans.

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research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

51 citations, January 1989 in “Journal of Investigative Dermatology”

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

research Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

227 citations, January 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

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