June 2026 in “Clinical Case Reports” This case report describes a 4-month-old child with symptoms suggesting multiple carboxylase deficiency, which responded well to biotin therapy, highlighting the importance of early diagnosis and treatment to prevent serious health issues in infants with similar unexplained metabolic acidosis and symptoms.
April 2018 in “Journal of Investigative Dermatology” This study suggests that human hair follicles may operate their own Cori cycle, synthesizing glycogen from lactate under conditions of lactic acidosis.
55 citations
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December 1987 in “Archives of Dermatology” This review discusses two genetic disorders affecting biotin metabolism, each resulting in distinctive skin and hair manifestations, and outlines the associated serious metabolic complications.
72 citations
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October 1988 in “Archives of Disease in Childhood” This study found that while biotin treatment improves clinical and biochemical symptoms in patients with biotinidase deficiency, some experience lasting neurological damage, and it is uncertain if early treatment can prevent this.
4 citations
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January 2018 in “Urology & Nephrology Open Access Journal” This case report details an instance of acute kidney injury following the inhalation of hair dye during a hairstyle session.