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Combined Drug Triads for Synergistic Neuroprotection in Retinal Degeneration

research Combined drug triads for synergic neuroprotection in retinal degeneration

6 citations , April 2022 in “Biomedicine & pharmacotherapy”

This review discusses the potential of using triads of repositioned medicines targeting multiple pathogenic mechanisms to prevent or delay retina degeneration, but reports no new results.

research Actualización en el tratamiento de la tricotilomanía

November 2024 in “Actas Dermo-Sifiliográficas”

This review outlines current treatment strategies for trichotillomania, noting that while cognitive-behavioral therapy is effective, N-acetylcysteine and memantine are also recommended due to their safety and efficacy, though evidence for other drugs like fluoxetine and naltrexone remains limited.

Update on the Treatment of Trichotillomania

research Actualización en el tratamiento de la tricotilomanía

May 2024 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

This review outlines current treatment strategies for trichotillomania, noting cognitive-behavioral therapy's success, while highlighting the promise and limitations of various pharmacological options.

research Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits

January 2024 in “International journal of molecular sciences”

This study found that boosting the synthesis of neural-derived 17β-estradiol effectively counteracted the impairment of hippocampal long-term potentiation caused by amyloid beta 1-42 in rat hippocampal slices, with the effect seemingly linked to glutamate NMDAR signaling.

research Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial

81 citations , July 2012 in “Translational Psychiatry”

In this pilot study, no significant differences were observed between memantine and placebo groups in young adults with Down syndrome on the primary memory outcomes, but some improvement was noted in a secondary measure.

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community Will we really be able to use pp405?

4 upvotes 10 months ago

People are skeptical about the effectiveness and availability of pp405 for hair regrowth, suggesting to use finasteride and minoxidil in the meantime. Some believe pp405 could offer significant regrowth, but it may take years before it's available.

community Anybody else obsessively searching for pp405 and counting the days?

69 upvotes 1 year ago

People are eagerly awaiting the release of PP405, a new hair loss treatment. Some are using minoxidil and finasteride in the meantime, but there are concerns about scams and unverified products.

community Promising reply to PP405 inquiry from Bill Lowry, one of its lead scientists

51 upvotes 1 year ago

PP405 is a potential hair loss treatment that may reactivate dormant hair follicles, with Phase 3 trials expected. Some users are cautious, suggesting using finasteride in the meantime, while others are skeptical about PP405's effectiveness.

community Waiting to start treatment until Kintor KX-826 Phase 2 data is published?

17 upvotes 4 years ago

People are waiting for KX-826 (Pyrilutamide) Phase 2 data to decide on hair loss treatments, with some considering finasteride or minoxidil in the meantime. Pyrilutamide is seen as a potentially stronger and safer alternative to finasteride, but concerns about side effects and availability remain.

community If Dr. Tsuji’s stem cell multiplication procedure works, will it be effective for those with DUPA?

40 upvotes 6 years ago

Dr. Tsuji's stem cell hair multiplication procedure may offer a future solution for hair loss, but it is initially expected to be very expensive, with prices potentially decreasing over time. In the meantime, users discuss using treatments like finasteride, despite side effects, to manage hair loss.

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