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Glossary MEK inhibitors

block enzymes involved in cell growth signaling pathways

MEK inhibitors, also known as MEKis or MEK1/2 inhibitors, are a class of drugs that block the activity of the MEK enzymes (MEK1 and MEK2), which are part of the MAPK/ERK signaling pathway. This pathway is crucial for cell division and survival, and its dysregulation is often implicated in various cancers. By inhibiting MEK, these drugs can help to slow down or stop the growth of cancer cells.

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research Cutaneous Toxicities of MEK Inhibitor Use in Children: A Comparison of Binimetinib and Selumetinib

3 citations , November 2024 in “Pediatric Dermatology”

This study found that dermatologic adverse events are common in children taking MEK inhibitors, with selumetinib patients experiencing less severe reactions and a lower risk of dosage adjustments. Age was noted as a factor in the likelihood of specific skin reactions.

research Melanotic pigmentation in excisional scar of melanoma patient who received BRAF and MEK inhibitors

1 citations , August 2018 in “Journal of The American Academy of Dermatology”

Patients with melanoma who saw dermatologists and were from higher-income areas were more likely to have follow-up visits, which was linked to lower mortality.

research 422 Human hair follicles express PD-L1, whose expression is down-regulated by EGFR and MEK inhibitors ex vivo. A potential mechanism for EGFR inhibitor induced sterile folliculitis

September 2019 in “Journal of Investigative Dermatology”

This study found that epidermal growth factor receptor and mitogen activated protein kinase inhibitors down-regulate PD-L1 expression in human hair follicles, which may contribute to sterile folliculitis in treated patients.

research 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes

April 2016 in “Journal of Investigative Dermatology”

This study found that trametinib and vemurafenib increased sebum production and gene expression related to lipid accumulation in hamster sebocytes, which may help explain certain side effects in patients.