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    Glossary MEK inhibitors

    block enzymes involved in cell growth signaling pathways

    MEK inhibitors, also known as MEKis or MEK1/2 inhibitors, are a class of drugs that block the activity of the MEK enzymes (MEK1 and MEK2), which are part of the MAPK/ERK signaling pathway. This pathway is crucial for cell division and survival, and its dysregulation is often implicated in various cancers. By inhibiting MEK, these drugs can help to slow down or stop the growth of cancer cells.

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    Research 10 of 474

    1. Cutaneous Toxicities of MEK Inhibitor Use in Children: A Comparison of Binimetinib and Selumetinib Pediatric Dermatology · 2024 · 3 citations
    2. Melanotic pigmentation in excisional scar of melanoma patient who received BRAF and MEK inhibitors Journal of The American Academy of Dermatology · 2018 · 1 citations
    3. 422 Human hair follicles express PD-L1, whose expression is down-regulated by EGFR and MEK inhibitors ex vivo. A potential mechanism for EGFR inhibitor induced sterile folliculitis Journal of Investigative Dermatology · 2019
    4. 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes Journal of Investigative Dermatology · 2016
    5. 861 EGFR/MEK inhibitor therapy induces partial hair follicle immune privilege collapse in vivo and ex vivo Journal of Investigative Dermatology · 2022
    6. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes 2019 · 32 citations
    7. Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic stem cell pool and resembles senescence driven skin aging Journal of Clinical Oncology · 2008 · 2 citations
    8. 645 MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma Journal of Investigative Dermatology · 2016
    9. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    10. Cutaneous toxicities of new treatments for melanoma Clinical & Translational Oncology · 2018 · 25 citations
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