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GlossaryMEK inhibitors

block enzymes involved in cell growth signaling pathways

MEK inhibitors, also known as MEKis or MEK1/2 inhibitors, are a class of drugs that block the activity of the MEK enzymes (MEK1 and MEK2), which are part of the MAPK/ERK signaling pathway. This pathway is crucial for cell division and survival, and its dysregulation is often implicated in various cancers. By inhibiting MEK, these drugs can help to slow down or stop the growth of cancer cells.

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research Cutaneous Drug Eruptions Associated With the Use of New Oncological Drugs

29 citations , January 2012 in “Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy”

New cancer drugs often cause skin and nail problems.

research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis

6 citations , December 2019 in “Frontiers in genetics”

GLI1 might protect against the start of skin cancer and is not linked to cancer severity.

Adverse Cutaneous Reactions to the New Second-Generation Tyrosine Kinase Inhibitors (Dasatinib, Nilotinib) in Chronic Myeloid Leukemia

research Adverse Cutaneous Reactions to the New Second-Generation Tyrosine Kinase Inhibitors (Dasatinib, Nilotinib) in Chronic Myeloid Leukemia

25 citations , November 2013 in “Journal of the American Academy of Dermatology”

Many patients on new leukemia drugs had mild to moderate skin reactions.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells

37 citations , November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

research The Ophthalmological Complications of Targeted Agents in Cancer Therapy: What Do We Need to Know as Ophthalmologists?

54 citations , September 2012 in “Acta ophthalmologica”

Cancer treatments can cause various eye problems, so eye doctors should know how to diagnose and treat these early.

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community Reql minoxidil vs fake minoxidil (right)

in Minoxidil 239 upvotes 7 months ago

Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.