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Glossary MEK inhibitors

block enzymes involved in cell growth signaling pathways

MEK inhibitors, also known as MEKis or MEK1/2 inhibitors, are a class of drugs that block the activity of the MEK enzymes (MEK1 and MEK2), which are part of the MAPK/ERK signaling pathway. This pathway is crucial for cell division and survival, and its dysregulation is often implicated in various cancers. By inhibiting MEK, these drugs can help to slow down or stop the growth of cancer cells.

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research Dihydrotestosterone Induces Keratinocyte Apoptosis by Activating ERK Signaling

August 2026 in “In Vivo”

This study found that DHT induces apoptosis in human keratinocyte cells via ERK activation, independently of androgen receptors and the Wnt/β-catenin pathway.

research The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

This review discusses the adverse skin effects of EGFR inhibitors used in cancer treatment, exploring their mechanisms and offering strategies for prevention and management, but reports no new experimental findings.

research Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs

29 citations , January 2012 in “Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy”

This review discusses the various skin, mucosa, and adnexa side effects associated with different chemotherapeutic agents and provides insights into their clinical presentation and management; it reports no new results.

research When bugs and drugs conspire: driving acneiform skin toxicity

1 citations , February 2020 in “The Journal of clinical investigation/The journal of clinical investigation”

This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.

research Sorafenib-induced eruption resembling pityriasis rubra pilaris

21 citations , July 2011 in “Journal of the American Academy of Dermatology”

This study reported a drug-induced pityriasis rubra pilaris-like eruption in a patient treated with sorafenib, suggesting a possible effect of sorafenib on keratinocyte biology.

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